The campus sits on 420 rolling acres in Walnut, California, located on the eastern edge of the Greater Los Angeles Area. The city of Walnut is considered one of the Best Small Towns to Live In by Money Magazine. A diverse suburb, Walnut is known for its nationally renowned schools and equestrian community. The city combines the charms of rural living with the benefits of being just 25 miles from Downtown Los Angeles and its incredible cultural and recreational activities.

Mt. San Antonio College serves everyone, from residents to working professionals and international students. Its local College District boundaries encompass the communities of Baldwin Park, Bassett, Charter Oak, Covina, Diamond Bar, the southern portion of Glendora, Hacienda Heights, City of Industry, Irwindale, La Puente, La Verne, Pomona, Rowland Heights, San Dimas, Valinda, Walnut, and West Covina.